Hsiu-chung Ou
Name Hsiu-chung Ou
Job title Professor
Office I406
Office number 6550; 1858
Ph.D., College of Biochemistry and Biotechnology, Chung-Shan Medical University, Taiwan
M.Sc., Institute of Neuroscience, Faculty of Life Sciences, Yang-Ming University,Taiwan
B.S., Department of Rehabilitation Medicine, Chung-Shan Medical University, Taiwan
Chairperson, Department of Physical Therapy, Asian University
Associate Professor, Department of Occupational Therapy, Asian University
Visiting Scholar, Departmnet of Physical Therapy, University of Alberta, Canada
Associate Professor, Department of Physical Therapy, China Medical University
Area of Research
Cardiovascular disease
Diabetes and arteriosclerosis
Portfolio http://research.asia.edu.tw/TchEportfolio/index_1/ouhc99#
Portfolio http://research.asia.edu.tw/TchEportfolio/index_1/ouhc99#
Year Paper Title
2023 邱燦宏(Tsan-Hung Chiu)、古昌文(Chang-Wen Ku)、何宗榮(Tsung-Jung Ho)、蔡昆霖(Kun-Ling Tsai)、楊奕彤(Yi-Dung Yang)、歐秀中(Hsiu-chung Ou)*、陳?儀(CHEN, HSIU-I), Schisanhenol ameliorates oxLDL-caused endothelial dysfunction by inhibiting LOX-1 signaling, ENVIRONMENTAL TOXICOLOGY, 2023
2022 Wang SH、Tsai KL、Chou WC、Cheng HC、Huang YT、歐秀中(Hsiu-chung Ou)、Chang YC(Chang YC)*, Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway, AMERICAN JOURNAL OF CHINESE MEDICINE, 2022
2021 白培英、Wan-Ching Chou、Shih-Hung Chan、Shu-Yih Wu、陳?儀(CHEN, HSIU-I)、李啟文(Li Chi Wen)、Pei-Ling Hsieh、Pei-Ming Chu、Yu-An Chen、歐秀中(Hsiu-chung Ou)*, Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1/AMPK Pathway in Endothelial Cells, AMERICAN JOURNAL OF CHINESE MEDICINE, 2021
2021 林美儀(Lin, Mei-Yi)、Wan-Ting Cheng、Hui-Ching Cheng、Wan-Ching Chou、陳?儀(Chen, Hsiu-I)、歐秀中(Hsiu-chung Ou)、蔡昆霖*, Baicalin Enhances Chemosensitivity to Doxorubicin in Breast Cancer Cells via Upregulation of Oxidative Stress-Mediated Mitochondria-Dependent Apoptosis, Antioxidants (Basel), 2021
2021 古昌文(Chang-Wen Ku)、Cecilia Hsuan Day、歐秀中(Hsiu-chung Ou)、何宗融(Tsung-Jung Ho)、Ray-Jade Chen、Velmurugan Bharath Kumar,、Wen-Yuan Lin、黃志揚(Huang, Chih-Yang), The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats, Open Life Sciences, 2021
2021 歐秀中(Hsiu-chung Ou)、朱培銘(Chu, Pei-Ming)、Yu?Ting Huang、Hui?Ching Cheng、Wan?Ching Chou、Hsin?Lun Yang、陳?儀(CHEN, HSIU-I)、蔡昆霖(Kun?Ling Tsa), Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses, Cell and Bioscience, 2021
2021 古昌文(Ku, Chang-Wen)、何宗融(Ho, Tsung-Jung)、黃志揚(Huang, Chih-Yang)、朱培銘(Chu, Pei-Ming)、歐秀中(Hsiu-chung Ou)、謝佩伶(Hsieh, Pei-Ling), Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway, AMERICAN JOURNAL OF CHINESE MEDICINE, 2021
2020 Shiu-Min Cheng、歐秀中(Hsiu-chung Ou), Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain, The American journal of Chinese medicine, vol.48 no.2 pp.391-406, 2020
2020 Hsiu-I Chen、歐秀中(Hsiu-chung Ou), Neuroprotective Effect of Rhodiola crenulata in D-Galactose-Induced Aging Model, The American journal of Chinese medicine, vol.48 no.2 pp.373-390, 2020
2020 Hsiu-I Chen、歐秀中、Chung-Yu Chen、Shao-Hong Y、鄭秀敏(Shiu-Min Cheng)、Xu-Bo Wu、李信達(Shin-Da Lee), Neuroprotective Effect of Rhodiola crenulata in D-Galactose-Induced Aging Model, AMERICAN JOURNAL OF CHINESE MEDICINE, 2020
2020 Lu CH、歐秀中(Hsiu-chung Ou)、Day CH、陳?儀(Chen HI)、白培英(Pai PY)、Lee CY、Chen RJ、Chang RL、Vijaya P. Viswanadha、黃志揚(Huang, Chih-Yang)*、歐秀中(Hsiu-chung Ou), Deep Sea Minerals Ameliorate Diabetic-Induced Inflammation via Inhibition of TNFα Signaling Pathways, ENVIRONMENTAL TOXICOLOGY, vol.35, 2020
2020 陳?儀(Hsiu-I. Chen)、Wei-Syun Hu、Meng-Yu Hung、歐秀中(Hsiu-chung Ou)、黃素華(Su-Hua Huang)、Pei-Tzu Hsu、Cecilia-Hsuan Day、Kuan-Ho Lin、Vijaya P Viswanadha(Vijaya P Viswanadha)*、郭薇雯(Wei-Wen Kuo)、歐秀中(Hsiu-chung Ou), Protective Effects of Luteolin Against Oxidative Stress and Mitochondrial Dysfunction in Endothelial Cells, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, vol.30 no.6 pp.1032-1043, 2020
2019 歐秀中(Ou, Hsiu-Chung)、Wan-Ching Chou、Pei-Ming Chu、Pei-Ling Hsieh、洪菁霞(Ching-Hsia Hung)、蔡昆霖(Kun-Ling Tsai)*, Fucoxanthin Protects against oxLDL-Induced Endothelial Damage via Activating the AMPK-Akt-CREB-PGC1α Pathway, MOLECULAR NUTRITION & FOOD RESEARCH, 2019
2019 Pandey S(Pandey S)*, Luteolin: a natural flavonoid enhances the longevity of HUVECs against oxidative stress by modulating AMPK/PKC pathway., The American journal of Chinese medicine, vol.47 no.3 pp.541-557, 2019
2019 歐秀中、Wan-Ching Chou、洪菁霞(Ching-Hsia Hung)、朱培銘(Pei-Ming Chu)、謝珮伶(Pei-Ling Hsieh)、Shih-Hung Chan、蔡昆霖(Kun-Ling Tsai)*, Galectin-3 aggravates ox-LDL-induced endothelial dysfunction through LOX-1 mediated signaling pathway, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2019
2019 Lu CH(Lu CH)*、Shen CY、Hsieh DJ、Lee CY、Chang RL、Ju DT、白培英(Pai PY)、Viswanadha VP、歐秀中(Ou Hsiu-Chung)、黃志揚(Huang CY), Deep ocean minerals inhibit IL-6 and IGFIIR hypertrophic signaling pathways to attenuate diabetes-induced hypertrophy in rat hearts., Journal of applied physiology, vol.127 no.2 pp.356-364, 2019
2018 Tsai KL(Tsai KL)*, Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells. Mol Nutr Food Res, IRISH JOURNAL OF AGRICULTURAL AND FOOD RESEARCH, vol.62 no.11 pp.e1700928-, 2018
2018 蔡昆霖(Tsai, Kun-Ling)、洪菁霞(Hung, Ching-Hsia)、詹世鴻(Chan, Shih-Hung)、謝佩伶(Hsieh, Pei-Ling)、歐秀中(Ou, Hsiu-Chung)、鄭詠馨(Cheng, Yung-Hsin)、朱培銘(Chu, Pei-Ming)*, Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells, MOLECULAR NUTRITION & FOOD RESEARCH, vol.62 no.11 pp.e1700928-, 2018
2017 Wen SY(Wen SY)*, Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis, PLoS One, vol.12 no.6 pp.e1709492-, 2017
2017 Huang YT(Huang YT)*, Diallyl trisulfide & diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats., PHYSICS OF PARTICLES AND NUCLEI, vol.114 no.3 pp.402-410, 2017
2017 Wen SY(Wen SY)*, Viswanadha VP, Kuo WW, Huang CY. Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis. PLoS One., PLoS One, vol.12 no.6 pp.e0179492-, 2017
2014 Lee CH,(Lee CH,)*, Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK/eNOS pathway., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol.15 no.6 pp.10334-10349, 2014
2013 Hsieh YL,(Hsieh YL,)*, Ginkgo biloba extract attenuates oxLDL-induced endothelial dysfunction via an AMPK-dependent mechanism, PHYSICS OF PARTICLES AND NUCLEI, vol.114 no.2 pp.274-285, 2013
2013 Cheng SM(Cheng SM)*, Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats, INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.167 no.2 pp.478-485, 2013
2012 Lee WJ,( Lee WJ,)*, Aspirin inhibits resistin-induced endothelial dysfunction: roles of ROS and Akt/eNOS/NO signaling pathway., JOURNAL OF VASCULAR SURGERY, vol.55 no.4 pp.1104-1115, 2012
2012 Tsai KL(Tsai KL)*, A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways., JOURNAL OF VASCULAR SURGERY, vol.23 no.5 pp.458-468, 2012
2012 Kun-Ling Tsai(Kun-Ling Tsai)*, Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway, MOLECULAR NUTRITION & FOOD RESEARCH, vol.55 no.2 pp.227-240, 2012
2011 Chen JY(Chen JY)*, Vinorelbine-induced oxidative injury in human endothelial cells mediated by AMPK/PKC/NADPH/NF-κB pathways., BIOCHEMICAL PHARMACOLOGY, vol.674 no.2-3 pp.227-233, 2011
2011 Tsai KL(Tsai KL)*, Green tea epigallocatechin-3-gallate (EGCG) reduced endothelial cells dysfunction and adhesion molecule expression induced by oxidized-LDL., BIOCHEMICAL PHARMACOLOGY, vol.82 no.12 pp.1807-1821, 2011
2010 Tsai KL(Tsai KL)*, EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, vol.108 no.6 pp.1745-1756, 2010
2007 Hsiu-Chung Ou(Hsiu-Chung Ou)*, Protective effects of magnolol against oxidized LDL-induced cytotoxicity in endothelial cells., JOURNAL OF VASCULAR SURGERY, vol.81 no.6 pp.421-432, 2007
2006 Sheu WH, Rosiglitazone inhibits endothelial proliferation and angiogenesis., LIFE SCIENCES, vol.2006 no.364 pp.196-204, 2006
2006 Hsiu-Chung Ou, Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells., CLINICA CHIMICA ACTA, vol.2006 no.364 pp.196-204, 2006
2005 Huang HM, Protective Effect of -Keto--Methyl-nValeric Acid on BV-2 Microglia under Hypoxia or Oxidative Stress, Annals of the New York Academy of Sciences, 2005
2005 Tsai KL(Tsai KL)*, Solanum Lyratum Thumb Prevent Oxidized Low-density Lipoprotein-induced Endothelial Dysfunction., Medicine & Science in Sports & Exercise, vol.41 no.5 pp.172-, 2005
2005 Chi-Feng Hung(Chi-Feng Hung)*, (-)Epigallocatechin-3-gallate (EGCG), a Polyphenolic Compound in Green Tea, Protetcs Against Endothelial Cells Inflammation via Oxidized LDL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol.96 no.1 pp.183-197, 2005
2005 Lee IT, Hypercholesterolemia, not metabolic syndrome, related to adhesion of monocytes to cultured endothelium in nondiabetic subjects. Metabolism., METABOLISM-CLINICAL AND EXPERIMENTAL, vol.2005 no.54 pp.1467-1471, 2005
2004 Shen CC, Protective effect of nicotinamide on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation., JOURNAL OF BIOMEDICAL SCIENCE, vol.2004 no.11 pp.472-481, 2004
2004 Huang HM, alpha-keto-beta-methyl- n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores., FREE RADICAL BIOLOGY AND MEDICINE, vol.2004 no.37 pp.1779-1789, 2004
2002 Mei-Jen Wang, Silymarin protects dopaminergic neurons against lipopolysaccharide- induced neurotoxicity by inhibiting microglia activation., EUROPEAN JOURNAL OF NEUROSCIENCE, vol.2002 no.16 pp.2103-2112, 2002
2002 Huang HM, Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population., JOURNAL OF NEURAL TRANSMISSION, vol.2002 no.109 pp.1415-21, 2002
2000 Kuo JS, Differential alteration of catecholamine release during chemical hypoxia is correlated with cell toxicity and is blocked by protein kinase C inhibitors in PC12 cells., JOURNAL OF CELLULAR BIOCHEMISTRY, vol.2000 no.79 pp.191-201, 2000
2000 Huang HM, Amyloid beta peptide impaired carbachol but not glutamate-mediated phosphoinositide pathways in cultured rat cortical neurons, CHINESE MEDICAL JOURNAL, vol.2000 no.25 pp.303-312, 2000
2000 Huang HM, Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons., LIFE SCIENCES, vol.2000 no.66 pp.1879-1892, 2000
Date of Publication Paper Title
2011.04 歐秀中(Hsiu-chung Ou), 2nd National Obesity Summit, Apr. 2011, Montreal, Canada
2010.08 歐秀中(Hsiu-chung Ou), Eighth Annual Scientific Sessions: Metabolic Signaling in the Cardiovascular System, Aug. 2010, Alberta, Canada
2010.04 歐秀中(Hsiu-chung Ou), Experimental Biology, 2010, Apr. 2010, Califonia, USA
2009.05 蔡昆霖、歐秀中(Hsiu-chung Ou), ACSM's Annual Meeting, May. 2009, Seattle, USA
2008.06 歐秀中(Hsiu-chung Ou), Society for Heart & Vascular Metabolism, Jun. 2008, Boston, USA
Project Title Participator Period
利用細胞模式探討人參皂?Rg3於退化性關節炎之保護效果 (ASIA-110-CMUH-11) 歐秀中(Hsiu-chung Ou)、邱燦宏、徐瑋璟 2021.11 ~ 2022.10
低能量電射改善化療藥物造成肌肉衰弱之效果探討:從分子機轉到動物研究 (109-2635-B-468-001) 歐秀中(Hsiu-chung Ou)、蔡昆霖(Kun-Ling Tsai) 2020.08 ~ 2021.07
探討氧化壓力下抗老化基因與Galetin-3交互作用保護內皮細胞凋亡與力腺體功能異常之機轉 (ASIA-108-CMUH-07) 歐秀中(Hsiu-chung Ou)、白培英(Pei-Ying Pai)、吳書毅(Shu-Yih Wu) 2019.11 ~ 2020.10
The antiatherogenic effects of sesamin in vitro and in vivo 2009.08 ~ 2012.07
Effects of polyphenolic compounds and exercise preconditioning protect against injury in a cerebral ischemia/reperfusion model in rat 2008.08 ~ 2009.07
Protective effect of sesamin on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation 2007.08 ~ 2008.07
Effects of ginkgo on oxLDL-promoted interaction between monocyte and vascular endothelium: regulation of redox status, adhesion molecules, and trans-endothelial migration (National Science Council) 2006.08 ~ 2007.07
Award Name Awarding Unit
中國醫藥大學健康照護學院研究傑出獎 請選擇
Category Course Code Course Title Year
大學日間部 TR300104A 神經物理治療實習 (二) 111
大學日間部 TR300035A 神經物理治療學(二) 111
大學日間部 TR300012A 生理學 111
大學日間部 TR300024A 基礎物理治療學(二) 111
大學日間部 TR300025A 基礎物理治療學實習(二) 111
大學日間部 TR300026A 公共衛生學 111
大學日間部 TR300044A 物理治療實證醫學 111
大學日間部 TR300046A 神經物理治療總論 111
大學日間部 TR300053A 臨床實習(四) 111
大學日間部 TR300054A 臨床實習(五) 111
大學日間部 TR300055A 臨床實習(六) 111
大學日間部 TR300090A 特殊族群運動治療 111
大學日間部 TR300093A 臨床推論與決策 111